Gene expressions of ubiquitin and hsp70 following focal ischaemia in rat brain
M Noga, T Hayashi, J Tanaka - Neuroreport, 1997 - journals.lww.com
EXPRESSION of genes coding for ubiquitin and heatshock protein (hsp) 70 were examined
by in situ hybridization using a rat model with permanent occlusion of the distal middle
cerebral artery (MCA). Only polyubiquitin (UbC) mRNA increased markedly following
ischaemia in the central zone of the MCA territory of the neocortex. UbC gene expression
reached the maximum level 4 h post-occlusion and remained elevated at 24 h. UbC
expression was retarded slightly compared with that of the hsp70 gene. UbB and Ub-S30 …
by in situ hybridization using a rat model with permanent occlusion of the distal middle
cerebral artery (MCA). Only polyubiquitin (UbC) mRNA increased markedly following
ischaemia in the central zone of the MCA territory of the neocortex. UbC gene expression
reached the maximum level 4 h post-occlusion and remained elevated at 24 h. UbC
expression was retarded slightly compared with that of the hsp70 gene. UbB and Ub-S30 …
